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Home / All Articles / Blood Lipids / Detailed Explanation of the Pathogenesis of Hyperlipidemia: Diagnostic Criteria, Etiology, and Classification

Detailed Explanation of the Pathogenesis of Hyperlipidemia: Diagnostic Criteria, Etiology, and Classification

2026-03-03

It's important to understand the pathogenesis of hyperlipidemia: Hyperlipidemia is generally defined as a blood cholesterol level exceeding 220 mg/100 ml, or triglycerides exceeding 150 mg/100 ml, LDL cholesterol exceeding 135 mg/100 ml, and HDL cholesterol below 35 mg/100 ml. Healthy individuals generally do not exceed these levels. The greater the deviation of these values ​​from the recommended range, the more severe the condition.

Hyperlipidemia is classified into primary and secondary types.

Primary hyperlipidemia results from a congenital defect in a step of lipoprotein metabolism or from a metabolic disorder caused by environmental factors. When a genetic factor is present, it is called hereditary or familial hyperlipidemia. Dietary habits, nutritional factors, lifestyle habits, and many other unknown factors are considered adverse factors.

Secondary hyperlipidemia is mainly secondary to diseases such as diabetes, chronic liver disease, nephrotic syndrome, hypothyroidism, obesity, or the effects of certain medications and immune system disorders.

The causes of elevated blood lipids are not singular; dietary factors are one of them. In addition, high blood lipids are associated with various diseases, including genetic disorders (such as familial hypercholesterolemia), diabetes, hypothyroidism, nephrotic syndrome, obesity, and atherosclerosis. All these diseases that can cause elevated blood lipids can potentially affect the normal metabolism of cholesterol in the body, leading to excessive accumulation in the blood. Atherosclerosis and coronary heart disease are the greatest dangers of high blood lipids.

« Analysis of common symptoms of hyperlipidemia: from silent onset to xanthoma manifestations
Analysis of the mechanisms of hyperlipidemia: Influence of endogenous and exogenous factors and age »
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